Extrusion technology is a recognized continuous manufacturing process in the pharmaceutical industry, which offers distinct advantages over batch production. In an extruder, many process steps are integrated, including feeding, melting, venting, and discharging. Upstream material handling and downstream equipment are connected with the extruder to complete the production operation. Below is a typical twin-screw extruder configuration.
The CIP cleaning kit simplifies cleaning operations.
Insert the cleaning hose into the adapter port and flush the screw and barrel with water.
The screw elements and barrel are detachable and can be cleaned in a washing machine.
After disconnecting the process units, they can be easily disassembled using special barrel tools.
Quick assembly and disassembly.
Stainless steel mirror polishing treatment.
Data acquisition and status monitoring of field-level pharmaceutical machinery and production lines.
It provides users with comprehensive user authority management and security strategies, including functions such as:
Audit trail.
Electronic signature.
Recipe management, and batch record reporting.
The entire operation process is recordable and traceable.
Database files are encrypted and tamper-proof with a proprietary format.
All data modifications are logged.
Historical data is backed up both locally and remotely to ensure data integrity and security.
HMI Page
Operational Logic
Hot Melt Extrusion (HME) is a process for dispersing Active Pharmaceutical Ingredients (APIs) into polymers. Commonly used polymeric carriers in the pharmaceutical industry include PVP, methacrylates, or cellulose-based carrier materials. During the hot melt extrusion process, mixtures of APIs, polymers and excipients are processed under specific temperature and pressure conditions.
The PROMIX series equipment homogenizes all materials, while high shear forces disperse the drug in the polymer carrier at the molecular level, forming a solid dispersion state. The extrudate exiting the extrusion die is then solidified by cooling.
In addition, HME technology has been proven to enable the molecular-level dispersion of Class II and Class IV poorly soluble drugs in polymer carriers, thereby enhancing the dissolution rate and bioavailability of the drugs.
In the solid lipid extrusion, also referred to as cold extrusion process, lipid materials are used to produce plastic masses.
Since most lipid materials have a low melting point or melting range, the extrusion process is also suitable for such thermosensitive APIs.
Another key advantage is that no additional solvents are required during extrusion, and there is no material solidification stage.
As the lipid material acts as the matrix, it will ultimately affect the solubility of the drug.
Benefiting from the continuous operation of twin screws, the extruder can perform granulation efficiently. In the wet extrusion and wet granulation processes, powdered excipients and APIs, together with liquid binders, are mixed in the PROMIX series equipment.
In the wet extrusion process, the agglomerated material is linearly extruded through die orifices for subsequent spheronization to produce pellets. For the wet granulation process, there are no die orifices.
Another granulation technique is melt granulation. In this process, powdered APIs are efficiently agglomerated and melted with the addition of binders, followed by cooling and solidification. Since the mixing intensity of the materials can be adjusted in the extruder, pellets with various properties can be manufactured.
Hot melt extrusion can be applied not only to oral pharmaceutical formulations such as tablets and pellets, but also to the production of topical dosage forms including implants and transdermal patches.
After mixing the active pharmaceutical ingredient (API) and excipients, the mixture is formed via melt extrusion deposition.
| Model | PROMIX-11 | PROMIX-16 | PROMIX-26S | PROMIX-32S | PROMIX-40S | PROMIX-50S |
|---|---|---|---|---|---|---|
| Diameter | 11mm | 16mm | 25.7mm | 31.8mm | 40.3mm | 50.3mm |
| Barrel Length | 460mm | 670mm | 1000mm | 1260mm | 1620mm | 1980mm |
| L/D | 40:1 | 40:1 | 40:1 | 40:1 | 40:1 | 40:1 |
| Motor Power | 2kw | 3.5kw | 37kw | 83kw | 110kw | 130kw |
| Max. Screw Speed | 1000rpm | 1000rpm | 900rpm | 900rpm | 900rpm | 900rpm |
| N.m Per Shaft | 6N.m | 9.5N.m | 140N.m | 315N.m | 600N.m | 980N.m |
| Specific Torque | 11 | 13 | 15 | 15 | 15 | 15 |
| L*W*H | 1200x750x1300 | 1200x780x1300 | 2600x740x1680 | 3800x760x1950 | 4050x780x1300 | 4500x800x1680 |
| Weight | 270kg | 305kg | 1500kg | - | - | - |
| Output | 0.2-2.5kg/h | 0.5-20kg/h | 50-200kg/h | 60-250kg/h | 80-300kg/h | 100-350kg/h |
Founded in 2015, Lemix is a professional manufacturer focusing on R&D, production and service of extrusion equipment. since 2026 year, we have two factories which covers an area around 10,000 square meters.
Our core business covers twin-screw extruders, hot-melt extruders, screw cleaning & disassembly machines, cooling system cleaners and barrel wear detectors. We also supply key spare parts including screw elements, barrels, shafts and gearboxes, together with full maintenance, repair and upgrade services. in addition, we import high-performance stainless steel and provide customized material solutions for barrels and screws, especially high-wear and corrosion-resistant Hastelloy alloys.
